Authors

Benjamin Longo-Mbenza^{1, 2*}, Héritier Mawalala¹, Etienne Mokondjimobe^{1, 2,} Henriette Poaty ^2,3, Lm Miguel ², Madone Mandina ⁴, Louise Kikontwe, Roger Wumba ⁴, Jean Robert Makulo ⁴, Aliocha Nkodila¹  Blaise Makoso ¹, Gédéon Longo Longo¹, Jean Claude Manzala¹, Jérôme Sokolo ⁴, Moise Mvitu Muaka^{1, 4}, Serge Malenga ¹, Mireille Nganga⁴, Venant Tchokonte-Nana⁵, Pius Kabututu Zakayi ⁴, Bruno Eto⁷, Ruffin Apalata⁸,  Raoul Gombet⁷, Reine Eboka-Loumingou Sakou^7
1lomo University Of Research, Kinshasa,
²faculte Des Sciences De La Sante, Brazzaville
³institut De La Recherche En Science De La Sante, Brazzaville
⁴faculte De Medecine, Cliniques Universitaires De Kinshasa, Kinshasa,
⁵faculty Of Health Sciences, University Des Montagnes, Bangangte, Cameroun,
⁶faculte Des Sciences Pharmaceutiques Et Biologiques De Lille, France
⁷universite Marien Ngouabi, Brazzaville
⁸walter Sisulu University, Mthatha, South Of Africa

Article Information

*Corresponding author: Benjamin Longo-Mbenza, lomo University Of Research, Kinshasa.
Received: October 07, 2021
Accepted: October 29, 2021
Published: November 03, 2021
Citation: Benjamin Longo-Mbenza, Héritier Mawalala, Etienne Mokondjimobe, Henriette Poaty, Lm Miguel et al  “The Management of Acute Coronary Syndrome, Cardio-Metabolic Risk, Geriatric Syndrome, Inflammasome, Genetics, Challenges Of Heart Failure And Cardiomyopathies In The Time Of Covid 19: Experience Of Lomo University Of Research In The Face Of Double Malnutrition, Immune Storms And Multiple Morbidity.” Clinical Case Reports and Clinical Study, 5(4); DOI: 10.61148/2766-8614/JCCRCS/094
Copyright: © 2021 Benjamin Longo-Mbenza. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: To describe the scientific management of acute coronary syndrome, cardio-metabolic risk, geriatric syndrome, inflammasome, genetics, challenges of heart failure and cardiomyopathies in the time of COVID-19.

Methods

The review of the literature provided evidence relating to the place of COVID-19, the origin of the immune storm, atherosclerosis, hepatic-vasculo-respiratory renal attacks and insulin resistance on the cardiovascular system.

Lomo University of Research evaluated structural markers, bio-markers of coinfection, oxidative stress, anxiety-depressive syndrome, inflammation, blood groups, sickle cell disease, metabolic syndrome, geriatric syndrome, and immunities on the myocardium and coronary circulation. Discriminant analysis and generalized exploratory analysis were used.

Results

Among the 400 patients admitted between March and June 2020, 50% (n = 200) developed the disease COVID-19. Age advancement, metabolic autoimmunity syndrome, elevated triglyceride, gamma GT, waist circumference, IL6, increased IGE, oxidized LDL, ferritin, mast cell, D-dimer, CD8 and platelet but the decrease in albuminemia, lymphocyte, CD4, HDL, FGR and vitamin D have discriminated against the stages of COVID-19.

The constellation of hepatitis C, insulin resistance, carotid thickening, sickle cell disease, blood group B, high blood pressure, abdominal obesity, G6PD deficiency, oxidative stress, anxiety, hemolytic microangiopathy, immune storm, polish glass pneumonia, hypercoagulability, stroke, type 2 diabetes mellitus, myocardial infarction characterized severe COVID-19. In contrast, dilated cardiomyopathy without atherosclerosis characterized moderate COVID-19. The supplement of vitamin D, vitamin C, herbal tea made from avocado, vitamin E and specific treatment for the comorbidity were administered.

Conclusion

COVID-19 defines comorbidity based on genetics, inflammation, geriatric syndrome, dysimmunity and cardio-metabolic risk

Keywords: COVID-19, Cardio-metabolic risk, Central Africa