Garima Rawat1*, Hema Malini Aiyer1, Bharat Bhushan Khurse2
1Junior Consultant Department of Pathology, Dharamshila Narayana Hospital, New Delhi
2Department of Surgical Oncology MMI Raipur, Raipur, Chhattisgarh
*Corresponding Author: Garima Rawat, M.D.S. Oral & Maxillofacial Pathology,Junior Consultant, Department of Pathology Dharamshila Narayana Superspeciality Hospital, New Delhi
Received: March 17, 2023
Accepted: May 18, 2023
Published: June 09, 2023
Citation: Garima Rawat, Hema Malini Aiyer, Bharat Bhushan Khurse (2023) “Wound healing and the quantum nature of viscosity and thermal diffusion of liquids”, International Journal of Medical Case Reports and Medical Research, 1(1); DOI: 10.61148/2994-6905/IJMCRMR/002
Copyright: © 2023 Garima Rawat. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly Cited.
Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial odontogenic tumor frequently involving the maxillary anterior region. It presents as an encapsulated slow growing lesion displacing the roots of associated teeth. The histopathological findings are characteristic and aid in diagnosis of this entity. We present a case of a 28 year old female who developed an expansile swelling in the anterior maxillary region which was reported as an Adenomatoid Odontogenic Tumor (AOT) post-surgical excision. This article discusses the hamartomatous vs true neoplastic nature of AOT.
Adenomatoid odontogenic tumor (AOT) is a rare encapsulated benign tumor arising from the odontogenic epithelium which is usually associated with an indolent behaviour. This neoplasm is characterized by the peculiar histopathological findings of rosette or duct like structures. The term AOT was purposed by Philipsen and Birn in the 1969 WHO classification.1-2 Before this nomenclature, this neoplasm traversed a long and dynamic journey of nomenclatures with the first one being called as “Cystic Adamantinoma” described by Harbitz. The irrefutable evidence supporting this tumor to be cystic in nature has been the point of discussion since long. Some authors like Ide et al advocate th AOT should be identified as an Adenomatoid Odontogenic cyst (AOC), however, another school of authors justifies that it is correctly classified as a tumor. The evidence supporting both schools of thoughts are available but in our opinion this neoplasm behaves like a true solid tumor with foci of cystic degeneration and should be continued to be treated as a tumor.2,3,5
The latest WHO classification places AOT in the Benign epithelial odontogenic tumor category and defines it as a “benign encapsulated epithelial odontogenic tumour that contains rosette or duct-like structures and has an indolent behaviour”.6
In this article we discuss a case of AOT in 28 year old female involving anterior maxilla with emphasis on the characteristic histopathological features.
A 28 year old female presented to the out patient department (OPD) of a tertiary care hospital with the chief complaint of a swelling on upper lip along with slight mobility of teeth in that region since few months. On extra-oral examination, the upper lip on the right side was slightly raised. Intra-oral examination revealed a firm to hard swelling on the right side of anterior maxillary region involving lateral incisor to first molar region. The associated teeth were grade 1 mobile and the overlying mucosa was congested and slightly tender on palpation. An orthopantomogram (OPG) was advised which revealed a well defined corticated unilocular radiolucency extending from maxillary second incisor medially to second molar laterally and superiorly reaching and obscuring the floor of maxillary sinus. The lesion was displacing and resorbing the apical third of the roots of maxillary first and second premolars and first molar (Figure 1A). Associated both premolars were tender on percussion. The clinico-radiological findings were favoring a benign lesion possibly benign odontogenic tumors like Ameloblastoma or Adenomatoid odontogenic tumor. Considering the slow growing nature and well delineated radiographic presentation of the lesion, a complete excision of the lesion was planned. Patient underwent surgical excision of the tumor by raising a flap and the tumor had caused thinning of the cortices (Figure 1B). The excised specimen was submitted to the pathology department for histopathological examination. The specimen submitted consisted of a rounded grey white to grey brown soft tissue piece encasing three teeth- maxillary canine and first and second premolars. Cut section showed solid areas with focal cystic change along with areas of hemorrhage (Figure 2A). The roots of both premolars were resorbed upto the cervical portion of the roots. Multiple sections of the specimen were submitted for microscopic examination. The hematoxylin and eosin stained sections showed encapsulated tumor composed of variable nodules of spindle, cuboidal and columnar epithelial odontogenic cells (Figure 2B). The cells are arranged in solid nodules, rosettes or duct like structures and plexiform strands at periphery. Few rosettes show eosinophilic secretory material (Figure 2C). Foci of detinoid matrix, calcification, hemorrhage & hyalinization are identified (Figure 2D). Separate bits of periosteum are unremarkable. The final diagnosis of Benign epithelial odontogenic tumor - consistent with Adenomatoid Odontogenic tumor was given. The patient was discharged uneventfully.
AOT is an uncommonly encountered odontogenic epithelial tumor which has had a debatable past juggling between cyst and tumor, though most evidence and even the present authors opine that AOT is best categorized as an odontogenic tumor. The origin of AOT is controversial, but as it arises in the tooth bearing area, it is thought to arise from the odontogenic epithelium. The nature of AOT ie true neoplasm vs hamartoma has also gained a lot of difference of opinion from various authors. The authors favouring it to be a hamartoma advocated that its limited size, minimal growth potential and the lack of recurrence even after incomplete removal is a feature of hamartomatous lesions. While on the other hand, the small size, anterior location and thus prompt removal prevent excessively large destructive lesion and all these point it to be a true neoplasm.3 The neoplasm has been time and again called as two-thirds tumor pertaining to 2/3rd of the cases affecting the anterior maxilla in females in second to third decade of life.1,5,7,8 Our patient was also a female in her second decade of life with tumor involving the anterior maxillary region. This odontogenic tumor has three radiographic variants- Follicular, extrafollicular and peripheral and as a characteristic it is usually small with slow progression.1, 4 In the present case being discussed, the lesion was a comparatively larger unilocular radiolucency with destruction and resorption of the roots of associated teeth. The histopathological features of adenomatoid odontogenic tumor are characteristic with lesion composed of tumor cells arranged in varying patterns from duct like areas to rosettes, nests, tubules and solid areas. The cells range from spindle to columnar in shape. Areas of cystic degeneration are commonly present in a fibrous stroma. Calcified deposits and small rounded acellular eosinophilic masses resembling dentinoid admixed with tumour cells are also present.5,6,9 The microscopic findings were similar in the present case also along with peripheral areas of the tumor showing plexiform strands of odontogenic epithelium.
Treatment is usually conservative with complete surgical excision/ enucleation of the tumor along with proper follow up. Recurrence has not been reported following proper surgical removal of the tumor.